Publications
2026
Dai W., Kempmann E., Rosato F., Nikolova M., Siukstaite L., Kaminski T., Booth A., Ishmael M.S.K., Wang C., Heath G.R., Beales P.A., Richter R.P., Romer W., Webb M.E. and Turnbull W.B.; Engineered Coiled-Coils Convert Cholera Toxin B-Pentamers into Programmable Membrane Fusogens. ACS Nano 20(20), 14645-14658 (2026). DOI: 10.1021/acsnano.6c01578
Pramanik A., Booth A., Kobza D., Brackenbury W.J., Connell S.D., Beales P.A. and Hughes T.A.; EGFR-Targeted and MMP-Activated Membranolytic Peptides Kill Cancer Cells Specifically In Vitro and Reduce Tumor Growth In Vivo. Mol. Pharmaceutics (2026). DOI: 10.1021/acs.molpharmaceut.5c01774
2025
Martinez J., Ingram N., Kapur N., Jayne D.G. and Beales P.A.; Composition-dependent tunability of the cell interactions of hybrid lipid – block copolymer vesicles. J. Colloid Interface Sci. 137664 (2025). DOI: 10.1016/j.jcis.2025.137664
Ridgway-Brown D., Leathard A.S., France O., Muench S.P., Webb M.E., Jeuken L.J.C., Henderson P.J.F., Taylor A.F. and Beales P.A.; Membrane Transport Modulates the pH-Regulated Feedback of an Enzyme Reaction Confined within Lipid Vesicles. ACS Nano 19, 9814–9825 (2025). DOI: 10.1021/acsnano.4c13048
Catania R., Heath G.R., Rappolt M., Muench S.P, Beales P.A. and Jeuken L.J.C.; Solid-supported polymer-lipid hybrid membrane for bioelectrochemistry of a membrane redox enzyme. RSC Appl. Interfaces (2025). DOI: 10.1039/D4LF00362D
2024
Warren J.P., Coe R.H., Culbert M.P., Dixon A.R., Miles D.E., Mengoni M., Beales P.A. and Wilcox R.K.; Injectable peptide-glycosaminoglycan hydrogels for soft tissue repair: in vitro assessment for nucleus augmentation. Mater. Adv. 5, 8665-8672 (2024). DOI: 10.1039/D4MA00613E
Martinez J., Ingram N., Kapur N., Jayne D.G. and Beales P.A.; Vesicle-based formulations for pain treatment: a narrative review. PAIN Reports 9, e1196 (2024). DOI: 10.1097/PR9.0000000000001196
Xu Z., Booth A., Rappolt M., Peckham M., Tyler A.I.I. and Beales P.A.; Topological and Morphological Membrane Dynamics in Giant Lipid Vesicles Driven by Monoolein Cubosomes. Angew. Chemie Int. Ed. 64, e202414970 (2025). DOI: 10.1002/anie.202414970
Martinez J., Maisey T., Ingram N., Kapur N., Beales P.A. and Jayne D.G.; Development and validation of a mouse model to investigate post surgical pain after laparotomy. Surgery Open Science 20, 106-115 (2024). DOI: 10.1016/j.sopen.2024.06.002
2023
Leathard A.S., Beales P.A. and Taylor A.F.; Design of oscillatory dynamics in numerical simulations of compartment-based enzyme systems. Chaos 33(12), 123128 (2023). [link]
Müller W.A., Beales P.A., Muniz A.R. and Jeuken L.J.C.; Unraveling the Phase Behavior, Mechanical Stability, and Protein Reconstitution Properties of Polymer-Lipid Hybrid Vesicles. Biomacromolecules 24(9), 4156 (2023). [link]
Stobie C.E. and Beales P.A.; Life, Matter, Poetry: Blurred Lines and Bilayered Representations of Materials Science. Leonardo 56(3), 314–319 (2023). [link]
Warren J.P., Culbert M.P., Miles D.E., Maude S., Wilcox R.K. and Beales P.A.; Controlling the self-assembly and material properties of β-sheet peptide hydrogels by modulating intermolecular interactions. Gels 9(6), 441 (2023). [link]
Seneviratne R., Coates G., Xu Z., Cornell C.E., Thompson R.F., Sadeghpour A., Maskell D.P., Jeuken L.J.C, Rappolt M. and Beales P.A.; High resolution membrane structures within hybrid lipid-polymer vesicles revealed by combining x-ray scattering and electron microscopy. Small 19, 2206267 (2023). [link]
2022
Protein corona alters the mechanisms of interaction between silica nanoparticles and lipid vesicles. Soft Matter 18, 5021 - 5026 (2022). [link]
Brown C.P., Cook K.R., Beales P.A. and Dougan L.; SAWstitch: exploring self-avoiding walks through hand embroidery. Phys. Educ. 57, 045029 (2022). [link]
Catania R., Machin J., Rappolt M., Muench S.P., Beales P.A. and Jeuken L.J.C.; Detergent-Free Functionalisation of Hybrid Vesicles with Membrane Proteins Using SMALPs. Macromolecules 55(9), 3415–3422 (2022). [link]
Miele Y., Jones S.J., Rossi F., Beales P.A. and Taylor A.F.; Collective Behavior of Urease pH Clocks in Nano- and Microvesicles Controlled by Fast Ammonia Transport. J. Phys. Chem. Lett. 13, 1979–1984 (2022). [link]
Seneviratne R., Catania R., Rappolt M., Jeuken L.J.C and Beales P.A.; Membrane mixing and dynamics in hybrid POPC/poly(1,2-butadiene-block-ethylene oxide) (PBd-b-PEO) lipid/block co-polymer giant vesicles. Soft Matter 18, 1294–1301 (2022). [link]
Culbert M.P., Warren J.P., Dixon A.R, Fermor H.L., Beales P.A. and Wilcox R.K.; Evaluation of injectable nucleus augmentation materials for the treatment of intervertebral disc degeneration. Biomaterials Science 10, 874-891 (2022). [link]
2021
Xu Z., Seddon J.M., Beales P.A., Rappolt M. and Tyler A.I.I.; Breaking Isolation to Form New Networks: pH-Triggered Changes in Connectivity Inside Lipid Nanoparticles. J. Am. Chem. Soc. 143(40), 16556–16565 (2021). [link]
Byrne M.J., Iadanza M.G., Arribas Perez M., Maskell D.P., George R.M., Hesketh, E.L., Beales P.A., Zack M.D., Berry C. and Thompson R.F.; Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane. Nat. Commun. 12, 2791 (2021). [link]
Warren J.P., Miles D.E., Kapur N., Wilcox R.K. and Beales P.A.; Hydrodynamic Mixing Tunes the Stiffness of Proteoglycan‐Mimicking Physical Hydrogels. Adv. Healthc. Mater. 10(11), 2001998 (2021). [link]
William N., Bamidoro F., Beales P.A., Drummond-Brydson R., Hondow N., Key S., Kulak A., Walsh A.C., Winter S. and Nelson L.A.; Tuning stable noble metal nanoparticles dispersions to moderate their interaction with model membranes. J. Colloid Interface Sci. 594, 101-112 (2021) [link]
Thangsunanag P., Lal N., Tiede C., Moul S., Robinson J.I., Knowles M.A., Stockley P.G., Beales P.A., Tomlinson D.C., McPherson M.J. and Millner P.A.; Affimer-based impedimetric biosensors for fibroblast growth factor receptor 3 (FGFR3): a novel tool for detection and surveillance of recurrent bladder cancer. Sens. Actuators B Chem. 326, 128829 (2021) [link].
2020
Booth A., Marklew C.J., Ciani B. and Beales P.A.; The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex. Faraday Discussions 232, 188-202 (2021). [link]
Rottet S., Iqbal S., Beales P.A., Lin A., Lee J., Rug M., Scott C. and Callaghan R.; Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein. Polymers 12(5), 1049 (2020). [link]
Seneviratne R., Jeuken L.J.C., Rappolt M. and Beales P.A.; Hybrid Vesicle Stability under Sterilisation and Preservation Processes Used in the Manufacture of Medicinal Formulations. Polymers 12(4), 914 (2020). [link]
Khan S., McCabe J., Hill K. and Beales P.A.; Biodegradable Hybrid Block Copolymer – Lipid Vesicles as Potential Drug Delivery Systems. J. Colloid Interface Sci. 562, 418-428 (2020). [link]
2019
, , , , , Mechanomodulation of lipid membranes by weakly aggregating silver nanoparticles. Biochemistry 58, 4761-4773 (2019). [link]
Booth A., Marklew C.J., Ciani B. and Beales P.A.; In vitro membrane remodelling by ESCRT is regulated by negative feedback from membrane tension. iScience 15, 173-184 (2019). [link]
Chand S., Beales P.A., Claeyssens F. and Ciani B.; Topography design in model membranes: Where biology meets physics. Experimental Biology and Medicine 244, 294-303 (2019). [link]
Jones S.J., Taylor A.F. and Beales P.A.; Towards feedback-controlled nanomedicines for smart, adaptive delivery. Experimental Biology and Medicine 244, 283-293 (2019). [link]
2018
Marklew C.J., Booth A., Beales P.A. and Ciani B.; Membrane remodelling by a lipidated endosomal sorting complex required for transport-IIIchimera, in vitro. Interface Focus 8, 20180035 (2018). [link]
Beales P.A., Ciani B. and Mann S.; The artificial cell: biology-inspired compartmentalization of chemical function. Interface Focus 8, 20180046 (2018). [link]
Werner M., Auth T., Beales P.A., Fleury J.B., Hook F., Kress H., van Lehn R.C., Muller M., Petrov E.P., Sarkisov L., Sommer J.U. and Baulin V.A.; Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context. Biointerphases 13 (2), 028501 (2018). [link]
Seneviratne R., Khan S., Moscrop E., Rappolt M., Muench S.P., Jeuken L.J.C. and Beales P.A.; A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability. Methods 147, 142 - 149 (2018) [link]
2017
Beales P.A.; Biophysics: A toehold in cell surface dynamics. Nature Nanotechnology 12, 404-406 (2017). [link]
Beales P.A., Khan S., Muench S.P. and Jeuken L.J.C.; Durable vesicles for reconstitution of membrane proteins in biotechnology. Biochem. Soc. Trans. 45(1), 15-26 (2017). [link]
2016
Khan S., Li M., Muench S.P., Jeuken L.J.C. and Beales P.A.; Durable Proteo-Hybrid Vesicles for the Extended Functional Lifetime of Membrane Proteins in Bionanotechnology. Chem. Commun. 52, 11020 - 11023 (2016) [link]
Petrache A.I., Machin D.C., Williamson D.J., Webb M.E. and Beales P.A.; Sortase-mediated labelling of lipid nanodiscs for cellular tracing. Mol. BioSyst. 12, 1760 - 1763 (2016). [link]
Miles D.E., Mitchell E.A., Kapur N., Beales P.A. and Wilcox R.K.; Peptide-Glycosaminoglycan hybrid hydrogels as an injectable intervention for spinal disc degeneration. J. Mater. Chem. B 4, 3225 - 3231 (2016). [link]
2015
Bueno Leite N., Aufderhorst-Roberts A., Palma M.S., Connell S.D., Ruggiero Neto J. and Beales P.A.; PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties. Biophys. J. 109 (5), 936 - 947 (2015). [link]
Beales P.A. and Ciani B.; Chemical compartmentalisation by membranes: from biological mechanism to biomimetic applications. Phys. Chem. Chem. Phys. 17, 15487 - 15488 (2015). [link]
Beales P.A., Ciani B. and Cleasby A.; Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. Phys. Chem. Chem. Phys. 17, 15489 - 15507 (2015). [link]
2014
Goodchild S.C., Sheynis T., Thompson R., Tipping K.W., Xue W.-F., Ranson N.A., Beales P.A., Hewitt E.W. and Radford S.E.; β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption is Enhanced by Endosomal Lipids and Acidic pH. PLoS ONE 9 (8), e104492 (2014). [link]
Gordon V.D., Beales P.A., Shearman G.C., Zhao Z., Seddon J.M., Poon W.C.K. and Egelhaaf S.U.; Solid-like Domains in Mixed Lipid Bilayers: Effect of Membrane Lamellarity and Transition Pathway. Advances in Planar Lipid Bilayers and Liposomes, 20, 137 - 154 (2014). [link]
Beales P.A. and Vanderlick T.K.; Application of nucleic acid - lipid conjugates for the programmable organisation of liposomal modules. Adv. Colloid Interface Sci. 207, 290 - 305 (2014). [link]
2013
Geerts N., Schreck C.F., Beales P.A., Shigematsu H., O'Hern C.S. and Vanderlick T.K.; Using DNA-driven assembled phospholipid nanodiscs as a scaffold for gold nanoparticle patterning. Langmuir 29 (42), 13089 - 13094 (2013). [link]
Xu J., Vanderlick T.K. and Beales P.A.; Lytic and Non-Lytic Permeabilization of Cardiolipin-Containing Lipid Bilayers Induced by Cytochrome c. PLoS ONE 8 (7), e69492 (2013). [link]
Bergstrom C.L., Beales P.A., Yang L., Vanderlick T.K. and Groves J.T.; Cytochrome c causes pore formation in cardiolipin-containing membranes. Proc. Natl. Acad. Sci. USA 110 (16), 6269 - 6274 (2013). [link]
Churchman A.H., Wallace R., Milne S.J., Brown A.P., Brydson R. and Beales P.A.; Serum Albumin enhances the Biomembrane Activity of ZnO Nanoparticles. Chem. Commun. 49 (39), 4172 - 4174 (2013). [link]
Beales P.A., Geerts N., Inampudi K.K., Shigematsu H., Wilson C.J. and Vanderlick T.K.; Reversible assembly of stacked membrane nanodiscs with reduced dimensionality and variable periodicity. J. Am. Chem. Soc. 135 (9), 3335–3338 (2013). [link]
2012
Zhang S., Nelson L.A. and Beales P.A.; Freezing or wrapping, the role of particle size behind the mechanism of nanoparticle - biomembrane interaction. Langmuir 28 (35), 12831-12837 (2012). [link]
Nam J., Vanderlick T.K. and Beales P.A.; Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes. Soft Matter 8, 7982-7988 (2012). [link]
2011
Beales P.A., Bergstrom C.L., Groves J.T. and Vanderlick T.K., Single Vesicle Observations of the Cardiolipin – Cytochrome c Interaction: Induction of Membrane Morphology Changes. Langmuir 27 (10), 6107-6115 (2011). [link]
Beales P.A., Nam J. and Vanderlick T.K.; Specific Adhesion between DNA-functionalized “Janus” Vesicles: Size-Limited Clusters. Soft Matter 7 (5), 1747 – 1755 (2011). [link]
Nam J., Beales P.A. and Vanderlick T.K.; Giant Phospholipid/Block Copolymer Hybrid Vesicles: Mixing Behavior and Domain Formation. Langmuir 27 (1), 1-6 (2011). [link]
2000 - 2010
Beales P.A. and Vanderlick T.K.; Partitioning of Membrane-Anchored DNA Between Coexisting Lipid Phases. J. Phys. Chem. B. 113 (42), 13678 – 13686 (2009). [link]
Beales P.A. and Vanderlick T.K.; DNA as Membrane-Bound Ligand-Receptor Pairs: Duplex Stability is Tuned by Intermembrane Forces. Biophys.J. 96 (4), 1554 – 1565 (2009). [link]
Beales P.A. and Vanderlick T.K.; Specific Binding of Different Vesicle Populations by the Hybridization of Membrane-Anchored DNA. J. Phys. Chem. A 111 (49), 12372 – 12380 (2007). [link]
Gordon V.D., Beales P.A., Zhao Z., Blake C., Mackintosh F.C., Olmsted P.D., Cates M.E., Egelhaaf S.U. and Poon W.C.K.; Lipid organization and the morphology of solid-like domains in phase-separating binary lipid membranes; J. Phys.: condens. matter 18 (32), L415 – L420 (2006). [link]
Beales P.A., Gordon V.D., Zhao Z., Egelhaaf S.U. and Poon W.C.K.; Solid-like domains in fluid membranes; J. Phys.: condens. matter 17 (45), S3341 – S3346 (2005). [link]
Poon W.C.K., Egelhaaf S.U., Beales P.A., Salonen A. and Sawyer L.; Protein crystallisation: scaling of charge and salt concentration in lysozyme solutions; J. Phys.: condens. matter 12 (35), L569 – L574 (2000). [link]