Publications
Preprints
Warren J.P., Coe R.H., Culbert M.P., Dixon A.R., Miles D.E., Mengoni M., Beales P.A. and Wilcox R.K.; Injectable peptide-glycosaminoglycan hydrogels for soft tissue repair: in vitro assessment for nucleus augmentation. EngrXiv (2023). doi.org/10.31224/2931
Xu Z., Rappolt M., Tyler A.I.I. and Beales P.A.; Cubosome-Induced Topological Transformations in Giant Vesicles. ChemRxiv (2022). doi.org/10.26434/chemrxiv-2022-6pbbv
2023
Leathard A.S., Beales P.A. and Taylor A.F.; Design of oscillatory dynamics in numerical simulations of compartment-based enzyme systems. Chaos 33(12), 123128 (2023). [link]
Müller W.A., Beales P.A., Muniz A.R. and Jeuken L.J.C.; Unraveling the Phase Behavior, Mechanical Stability, and Protein Reconstitution Properties of Polymer-Lipid Hybrid Vesicles. Biomacromolecules 24(9), 4156 (2023). [link]
Stobie C.E. and Beales P.A.; Life, Matter, Poetry: Blurred Lines and Bilayered Representations of Materials Science. Leonardo 56(3), 314–319 (2023). [link]
Warren J.P., Culbert M.P., Miles D.E., Maude S., Wilcox R.K. and Beales P.A.; Controlling the self-assembly and material properties of β-sheet peptide hydrogels by modulating intermolecular interactions. Gels 9(6), 441 (2023). [link]
Seneviratne R., Coates G., Xu Z., Cornell C.E., Thompson R.F., Sadeghpour A., Maskell D.P., Jeuken L.J.C, Rappolt M. and Beales P.A.; High resolution membrane structures within hybrid lipid-polymer vesicles revealed by combining x-ray scattering and electron microscopy. Small 19, 2206267 (2023). [link]
2022
Protein corona alters the mechanisms of interaction between silica nanoparticles and lipid vesicles. Soft Matter 18, 5021 - 5026 (2022). [link]
Brown C.P., Cook K.R., Beales P.A. and Dougan L.; SAWstitch: exploring self-avoiding walks through hand embroidery. Phys. Educ. 57, 045029 (2022). [link]
Catania R., Machin J., Rappolt M., Muench S.P., Beales P.A. and Jeuken L.J.C.; Detergent-Free Functionalisation of Hybrid Vesicles with Membrane Proteins Using SMALPs. Macromolecules 55(9), 3415–3422 (2022). [link]
Miele Y., Jones S.J., Rossi F., Beales P.A. and Taylor A.F.; Collective Behavior of Urease pH Clocks in Nano- and Microvesicles Controlled by Fast Ammonia Transport. J. Phys. Chem. Lett. 13, 1979–1984 (2022). [link]
Seneviratne R., Catania R., Rappolt M., Jeuken L.J.C and Beales P.A.; Membrane mixing and dynamics in hybrid POPC/poly(1,2-butadiene-block-ethylene oxide) (PBd-b-PEO) lipid/block co-polymer giant vesicles. Soft Matter 18, 1294–1301 (2022). [link]
Culbert M.P., Warren J.P., Dixon A.R, Fermor H.L., Beales P.A. and Wilcox R.K.; Evaluation of injectable nucleus augmentation materials for the treatment of intervertebral disc degeneration. Biomaterials Science 10, 874-891 (2022). [link]
2021
Xu Z., Seddon J.M., Beales P.A., Rappolt M. and Tyler A.I.I.; Breaking Isolation to Form New Networks: pH-Triggered Changes in Connectivity Inside Lipid Nanoparticles. J. Am. Chem. Soc. 143(40), 16556–16565 (2021). [link]
Byrne M.J., Iadanza M.G., Arribas Perez M., Maskell D.P., George R.M., Hesketh, E.L., Beales P.A., Zack M.D., Berry C. and Thompson R.F.; Cryo-EM structures of an insecticidal Bt toxin reveal its mechanism of action on the membrane. Nat. Commun. 12, 2791 (2021). [link]
Warren J.P., Miles D.E., Kapur N., Wilcox R.K. and Beales P.A.; Hydrodynamic Mixing Tunes the Stiffness of Proteoglycan‐Mimicking Physical Hydrogels. Adv. Healthc. Mater. 10(11), 2001998 (2021). [link]
William N., Bamidoro F., Beales P.A., Drummond-Brydson R., Hondow N., Key S., Kulak A., Walsh A.C., Winter S. and Nelson L.A.; Tuning stable noble metal nanoparticles dispersions to moderate their interaction with model membranes. J. Colloid Interface Sci. 594, 101-112 (2021) [link]
Thangsunanag P., Lal N., Tiede C., Moul S., Robinson J.I., Knowles M.A., Stockley P.G., Beales P.A., Tomlinson D.C., McPherson M.J. and Millner P.A.; Affimer-based impedimetric biosensors for fibroblast growth factor receptor 3 (FGFR3): a novel tool for detection and surveillance of recurrent bladder cancer. Sens. Actuators B Chem. 326, 128829 (2021) [link].
2020
Booth A., Marklew C.J., Ciani B. and Beales P.A.; The influence of phosphatidylserine localisation and lipid phase on membrane remodelling by the ESCRT-II/ESCRT-III complex. Faraday Discussions 232, 188-202 (2021). [link]
Rottet S., Iqbal S., Beales P.A., Lin A., Lee J., Rug M., Scott C. and Callaghan R.; Characterisation of Hybrid Polymersome Vesicles Containing the Efflux Pumps NaAtm1 or P-Glycoprotein. Polymers 12(5), 1049 (2020). [link]
Seneviratne R., Jeuken L.J.C., Rappolt M. and Beales P.A.; Hybrid Vesicle Stability under Sterilisation and Preservation Processes Used in the Manufacture of Medicinal Formulations. Polymers 12(4), 914 (2020). [link]
Khan S., McCabe J., Hill K. and Beales P.A.; Biodegradable Hybrid Block Copolymer – Lipid Vesicles as Potential Drug Delivery Systems. J. Colloid Interface Sci. 562, 418-428 (2020). [link]
2019
, , , , , Mechanomodulation of lipid membranes by weakly aggregating silver nanoparticles. Biochemistry 58, 4761-4773 (2019). [link]
Booth A., Marklew C.J., Ciani B. and Beales P.A.; In vitro membrane remodelling by ESCRT is regulated by negative feedback from membrane tension. iScience 15, 173-184 (2019). [link]
Chand S., Beales P.A., Claeyssens F. and Ciani B.; Topography design in model membranes: Where biology meets physics. Experimental Biology and Medicine 244, 294-303 (2019). [link]
Jones S.J., Taylor A.F. and Beales P.A.; Towards feedback-controlled nanomedicines for smart, adaptive delivery. Experimental Biology and Medicine 244, 283-293 (2019). [link]
2018
Marklew C.J., Booth A., Beales P.A. and Ciani B.; Membrane remodelling by a lipidated endosomal sorting complex required for transport-IIIchimera, in vitro. Interface Focus 8, 20180035 (2018). [link]
Beales P.A., Ciani B. and Mann S.; The artificial cell: biology-inspired compartmentalization of chemical function. Interface Focus 8, 20180046 (2018). [link]
Werner M., Auth T., Beales P.A., Fleury J.B., Hook F., Kress H., van Lehn R.C., Muller M., Petrov E.P., Sarkisov L., Sommer J.U. and Baulin V.A.; Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context. Biointerphases 13 (2), 028501 (2018). [link]
Seneviratne R., Khan S., Moscrop E., Rappolt M., Muench S.P., Jeuken L.J.C. and Beales P.A.; A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability. Methods 147, 142 - 149 (2018) [link]
2017
Beales P.A.; Biophysics: A toehold in cell surface dynamics. Nature Nanotechnology 12, 404-406 (2017). [link]
Beales P.A., Khan S., Muench S.P. and Jeuken L.J.C.; Durable vesicles for reconstitution of membrane proteins in biotechnology. Biochem. Soc. Trans. 45(1), 15-26 (2017). [link]
2016
Khan S., Li M., Muench S.P., Jeuken L.J.C. and Beales P.A.; Durable Proteo-Hybrid Vesicles for the Extended Functional Lifetime of Membrane Proteins in Bionanotechnology. Chem. Commun. 52, 11020 - 11023 (2016) [link]
Petrache A.I., Machin D.C., Williamson D.J., Webb M.E. and Beales P.A.; Sortase-mediated labelling of lipid nanodiscs for cellular tracing. Mol. BioSyst. 12, 1760 - 1763 (2016). [link]
Miles D.E., Mitchell E.A., Kapur N., Beales P.A. and Wilcox R.K.; Peptide-Glycosaminoglycan hybrid hydrogels as an injectable intervention for spinal disc degeneration. J. Mater. Chem. B 4, 3225 - 3231 (2016). [link]
2015
Bueno Leite N., Aufderhorst-Roberts A., Palma M.S., Connell S.D., Ruggiero Neto J. and Beales P.A.; PE and PS Lipids Synergistically Enhance Membrane Poration by a Peptide with Anticancer Properties. Biophys. J. 109 (5), 936 - 947 (2015). [link]
Beales P.A. and Ciani B.; Chemical compartmentalisation by membranes: from biological mechanism to biomimetic applications. Phys. Chem. Chem. Phys. 17, 15487 - 15488 (2015). [link]
Beales P.A., Ciani B. and Cleasby A.; Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments. Phys. Chem. Chem. Phys. 17, 15489 - 15507 (2015). [link]
2014
Goodchild S.C., Sheynis T., Thompson R., Tipping K.W., Xue W.-F., Ranson N.A., Beales P.A., Hewitt E.W. and Radford S.E.; β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption is Enhanced by Endosomal Lipids and Acidic pH. PLoS ONE 9 (8), e104492 (2014). [link]
Gordon V.D., Beales P.A., Shearman G.C., Zhao Z., Seddon J.M., Poon W.C.K. and Egelhaaf S.U.; Solid-like Domains in Mixed Lipid Bilayers: Effect of Membrane Lamellarity and Transition Pathway. Advances in Planar Lipid Bilayers and Liposomes, 20, 137 - 154 (2014). [link]
Beales P.A. and Vanderlick T.K.; Application of nucleic acid - lipid conjugates for the programmable organisation of liposomal modules. Adv. Colloid Interface Sci. 207, 290 - 305 (2014). [link]
2013
Geerts N., Schreck C.F., Beales P.A., Shigematsu H., O'Hern C.S. and Vanderlick T.K.; Using DNA-driven assembled phospholipid nanodiscs as a scaffold for gold nanoparticle patterning. Langmuir 29 (42), 13089 - 13094 (2013). [link]
Xu J., Vanderlick T.K. and Beales P.A.; Lytic and Non-Lytic Permeabilization of Cardiolipin-Containing Lipid Bilayers Induced by Cytochrome c. PLoS ONE 8 (7), e69492 (2013). [link]
Bergstrom C.L., Beales P.A., Yang L., Vanderlick T.K. and Groves J.T.; Cytochrome c causes pore formation in cardiolipin-containing membranes. Proc. Natl. Acad. Sci. USA 110 (16), 6269 - 6274 (2013). [link]
Churchman A.H., Wallace R., Milne S.J., Brown A.P., Brydson R. and Beales P.A.; Serum Albumin enhances the Biomembrane Activity of ZnO Nanoparticles. Chem. Commun. 49 (39), 4172 - 4174 (2013). [link]
Beales P.A., Geerts N., Inampudi K.K., Shigematsu H., Wilson C.J. and Vanderlick T.K.; Reversible assembly of stacked membrane nanodiscs with reduced dimensionality and variable periodicity. J. Am. Chem. Soc. 135 (9), 3335–3338 (2013). [link]
2012
Zhang S., Nelson L.A. and Beales P.A.; Freezing or wrapping, the role of particle size behind the mechanism of nanoparticle - biomembrane interaction. Langmuir 28 (35), 12831-12837 (2012). [link]
Nam J., Vanderlick T.K. and Beales P.A.; Formation and dissolution of phospholipid domains with varying textures in hybrid lipo-polymersomes. Soft Matter 8, 7982-7988 (2012). [link]
2011
Beales P.A., Bergstrom C.L., Groves J.T. and Vanderlick T.K., Single Vesicle Observations of the Cardiolipin – Cytochrome c Interaction: Induction of Membrane Morphology Changes. Langmuir 27 (10), 6107-6115 (2011). [link]
Beales P.A., Nam J. and Vanderlick T.K.; Specific Adhesion between DNA-functionalized “Janus” Vesicles: Size-Limited Clusters. Soft Matter 7 (5), 1747 – 1755 (2011). [link]
Nam J., Beales P.A. and Vanderlick T.K.; Giant Phospholipid/Block Copolymer Hybrid Vesicles: Mixing Behavior and Domain Formation. Langmuir 27 (1), 1-6 (2011). [link]
2000 - 2010
Beales P.A. and Vanderlick T.K.; Partitioning of Membrane-Anchored DNA Between Coexisting Lipid Phases. J. Phys. Chem. B. 113 (42), 13678 – 13686 (2009). [link]
Beales P.A. and Vanderlick T.K.; DNA as Membrane-Bound Ligand-Receptor Pairs: Duplex Stability is Tuned by Intermembrane Forces. Biophys.J. 96 (4), 1554 – 1565 (2009). [link]
Beales P.A. and Vanderlick T.K.; Specific Binding of Different Vesicle Populations by the Hybridization of Membrane-Anchored DNA. J. Phys. Chem. A 111 (49), 12372 – 12380 (2007). [link]
Gordon V.D., Beales P.A., Zhao Z., Blake C., Mackintosh F.C., Olmsted P.D., Cates M.E., Egelhaaf S.U. and Poon W.C.K.; Lipid organization and the morphology of solid-like domains in phase-separating binary lipid membranes; J. Phys.: condens. matter 18 (32), L415 – L420 (2006). [link]
Beales P.A., Gordon V.D., Zhao Z., Egelhaaf S.U. and Poon W.C.K.; Solid-like domains in fluid membranes; J. Phys.: condens. matter 17 (45), S3341 – S3346 (2005). [link]
Poon W.C.K., Egelhaaf S.U., Beales P.A., Salonen A. and Sawyer L.; Protein crystallisation: scaling of charge and salt concentration in lysozyme solutions; J. Phys.: condens. matter 12 (35), L569 – L574 (2000). [link]